Editorial: Can an Increase in Antineutrophil Cytoplasmic Autoantibody Titer Predict Relapses in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis?

Editorial: Can an Increase in Antineutrophil Cytoplasmic Autoantibody Titer Predict Relapses in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis?

Treatment of antineutrophil cytoplasmic antibody-associated vasculitis.

PURPOSE OF REVIEW The primary idiopathic small-vessel vasculitis syndromes include granulomatosis with polyangiitis, Churg-Strauss syndrome, and microscopic polyangiitis. These disorders are commonly referred to as antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides and prominently affect the pulmonary vasculature. Although significant progress has been made in the management of ...

The neutrophil in antineutrophil cytoplasmic autoantibody-associated vasculitis.

Necrotizing, small-vessel vasculitis develops in patients with circulating ANCAs. Neutrophils and monocytes harbor the two major ANCA antigens, PR3 and MPO. A whole body of in vitro experiments implicated ANCA-activated neutrophil effector functions in the pathogenesis of vasculitis, whereas the role of monocytes is less well-characterized. Mouse models for anti-MPO-induced vasculitis were deve...

Perinuclear antineutrophil cytoplasmic antibody-associated vasculitis in an elderly woman.

Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis encompasses 3 conditions: eosinophilic granulomatosis with polyangiitis (EGPA; formerly named Churg-Strauss syndrome), granulomatosis with polyangiitis (GPA; formerly named Wegener granulomatosis), and microscopic polyangiitis.1 Diagnosing ANCA-associated small-vessel vasculitis is challenging for clinicians because of its infrequ...

Antineutrophil cytoplasmic autoantibody-associated glomerulonephritis in children.

Aretrospective investigation was conducted by members of the Japanese Society for Pediatric Nephrology from 1990 to 1997 to define the clinical features and outcome of antineutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis in children. Thirty-four ANCA-seropositive Japanese pediatric patients with biopsy-proven pauci-immune necrotizing crescentic glomerulonephritis were id...